Reversible Posterior Leukoencephalopathy Syndrome Induced by Pazopanib

Posterior Reversible Leukoencephalopathy Syndrome Associated with Pazopanib

A 62-year-old female patient with metastatic renal cell carcinoma under third-line treatment with pazopanib for 8 weeks suddenly developed severe headaches, grand mal seizures and paresis of the left arm in combination with gait instability as well as nausea and vomiting during her vacation abroad. The emergency physician measured systolic blood pressure values over 300 mm Hg and suspected a st...

Linezolid-induced posterior reversible leukoencephalopathy syndrome.

OBJECTIVE To describe a 71-year-old woman who developed clinical and neuroradiological features of posterior reversible leukoencephalopathy syndrome with a compromised blood-brain barrier after 5 days of intravenous linezolid therapy for an infected hip prosthesis. DESIGN Case report. SETTING Academic research. MAIN OUTCOME MEASURES Posterior reversible leukoencephalopathy syndrome was do...

Reversible posterior leukoencephalopathy syndrome.

Reversible Posterior Leukoencephalopathy Syndrome

Hinchey et al used the term „reversible posterior leukoencephalopathy syndrome“ in 1996 to describe a syndrome characterized by headache, confusion, seizures and vision disturbances, including cortical blindness, connected with reversible changes on brain magnetic resonance imaging (MRI) which pointed to the white matter eodema, predominantly in the posterior brain regions (1). Initially, this ...

[Reversible posterior leukoencephalopathy syndrome associated with carbamazepine-induced hypertension].

A 21-year-old man developed idiopathic trigeminal neuralgia, and was admitted to our hospital. Although neuralgia was promptly resolved after oral carbamazepine (CBZ) administration, he developed arterial hypertension (from 110/60 mmHg to 170/126 mmHg) followed by consciousness disturbance several days after the initiation of carbamazepine. MRI T2-weighted, FLAIR and ADC images demonstrated tra...